drug

D-serine

as of 2026-07-01
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at a glance
small molecule
Pre-approval / investigational in the US
Developed by Nathan Kline Institute for Psychiatric Research
14 trials in the graph
Synthesized from structured facts only — each point cited above.

Mechanism & identity

Modality
small molecule

Indications

Trials

14
D-serine AudRem: R33 Phase
NCT05046353Phase 1, Phase 2Suspended
The Effect of D-serine as add-on Therapy in Recent-onset Psychosis
NCT04140773—Terminated
D-serine in Schizophrenia
NCT03702933—Unknown
D-serine Augmentation of Neuroplasticity
NCT03711500Phase 1, Phase 2Completed
D-Serine Treatment For Tardive Dyskinesia
NCT01804920—Unknown
D-serine and Cognitive Remediation in Schizophrenia
NCT02156908Phase 2Completed
High Dose D-Serine as Adjuvant Treatment for Recent Onset Schizophrenia
NCT01459029Phase 2Unknown
N-methyl-D-aspartic Acid (NMDA) and Cognitive Remediation in Schizophrenia
NCT01474395Phase 2Unknown
D-serine Monotherapy for Schizophrenia
NCT00816894Phase 2Completed
D-serine for the Schizophrenia Prodrome
NCT00826202Phase 2Completed
D-Serine Treatment of Negative Symptoms and Cognitive Deficits in Schizophrenia
NCT00237809Phase 3Completed
Safety and Effectiveness of D-serine in Schizophrenia
NCT00322023Phase 2Completed
D-Serine for Enhancing Cognitive Retraining for the Treatment of Schizophrenia
NCT00237848Phase 3Completed
Israel Multicenter D-Serine Study (IMSER) for the Treatment of Schizophrenia
NCT00138775Phase 2Unknown

KOLs & investigators

8
Joshua T Kantrowitz, MDKOL score 16
Mark Weiser, MDKOL score 9
Daniel C. Javitt, MD, PhDKOL score 8
Deepak Cyril D'Souza, MDKOL score 7
Uriel Heresco-Levy, MDKOL score 5
Deepak C D'Souza, M.D.KOL score 5
Amit Lotan, MD
Bernard Lerer, MD

Facts & assertions

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relationships
The graph out of here
developer
Nathan Kline Institute for Psychiatric Research
company
trial
D-serine AudRem: R33 Phase
PHASE1, PHASE2
trial
The Effect of D-serine as add-on Therapy in Recent-onset Psychosis
NA
trial
D-serine in Schizophrenia
trial
D-serine Augmentation of Neuroplasticity
PHASE1, PHASE2
trial
D-Serine Treatment For Tardive Dyskinesia
NA
trial
indication
Schizophrenia
indication
Schizo Affective Disorder
indication
Schizophrenia
indication
Tardive Dyskinesia
indication
KOL
Joshua T Kantrowitz, MD
KOL score 16
person
Mark Weiser, MD
KOL score 9
person
Daniel C. Javitt, MD, PhD
KOL score 8
person
Deepak Cyril D'Souza, MD
KOL score 7
person