person

Stephen Brannan, MD

ORCID 0000-0003-0922-5970
as of 2026-07-01
at a glance
Roles: Study Director, Author
KOL signal score 39
20 publications · 9 high-value
Cross-drug reach: 1 competitor drugs
Synthesized from structured facts only — each point cited above.

Profile

Affiliation
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Roles
Study Director, Author
KOL signal
39
Publications
20 (9 high-value)
Trial investigator
no

Publishes on

1 drugs

Trials led

1

Publications & congress

20
Long-Term Safety and Efficacy of Xanomeline and Trospium Chloride in Schizophrenia: A 52-Week Open-Label Extension Trial.
The American journal of psychiatry · 2026 · high-value
The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials.
The American journal of psychiatry · 2025 · high-value
Safety and Tolerability of Xanomeline and Trospium Chloride in Schizophrenia: Pooled Results From the 5-Week, Randomized, Double-Blind, Placebo-Controlled EMERGENT Trials.
The Journal of clinical psychiatry · 2025 · high-value
Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia: A Randomized Clinical Trial.
JAMA psychiatry · 2024 · high-value
Efficacy of KarXT on negative symptoms in acute schizophrenia: A post hoc analysis of pooled data from 3 trials.
Schizophrenia research · 2024 · high-value
Efficacy and safety of the muscarinic receptor agonist KarXT (xanomeline-trospium) in schizophrenia (EMERGENT-2) in the USA: results from a randomised, double-blind, placebo-controlled, flexible-dose phase 3 trial.
Lancet (London, England) · 2024 · high-value
Evidence of trospium's ability to mitigate cholinergic adverse events related to xanomeline: phase 1 study results.
Psychopharmacology · 2023 · high-value
Antipsychotic Efficacy of KarXT (Xanomeline-Trospium): Post Hoc Analysis of Positive and Negative Syndrome Scale Categorical Response Rates, Time Course of Response, and Symptom Domains of Response in a Phase 2 Study.
The Journal of clinical psychiatry · 2022 · high-value
Effectiveness of KarXT (xanomeline-trospium) for cognitive impairment in schizophrenia: post hoc analyses from a randomised, double-blind, placebo-controlled phase 2 study.
Translational psychiatry · 2022 · high-value
Effects of Xanomeline and Trospium Chloride for Negative Symptoms Associated With Physical Activity in Younger and Older Adults with Schizophrenia: Results From a 52-Week, Open-label Clinical Trial.
Schizophrenia research · 2026
Low incidence of extrapyramidal symptoms following treatment with a muscarinic agonist medication for schizophrenia.
Schizophrenia research · 2026
Does Xanomeline/Trospium Have Unique Benefits for Cognitive Impairment Associated With Schizophrenia? Response to Tandon.
The American journal of psychiatry · 2025
Capturing changes in social functioning and positive affect using ecological momentary assessment during a 12-month trial of xanomeline and trospium chloride in schizophrenia.
Schizophrenia research · 2025
Methods to address functional unblinding of raters in CNS trials.
Translational psychiatry · 2025
Author Correction: Efficacy of xanomeline and trospium chloride in schizophrenia: pooled results from three 5-week, randomized, double-blind, placebo-controlled, EMERGENT trials.
Schizophrenia (Heidelberg, Germany) · 2025
Efficacy of xanomeline and trospium chloride in schizophrenia: pooled results from three 5-week, randomized, double-blind, placebo-controlled, EMERGENT trials.
Schizophrenia (Heidelberg, Germany) · 2024

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